Enzymes, proteins, riboproteins and signaling pathways.


The FYN gene that encodes the enzyme Fyn is a member of the protein tyrosine kinase oncogene family and is related to SRC, FGR, and YES.

Fyn is a membrane-associated tyrosine kinase implicated in the control of cell growth. Fyn protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. There exist alternatively spliced transcript variants encoding distinct isoforms of Fyn.

The intracellular tails of CD3 molecules contain a single conserved motif termed the immunoreceptor tyrosine-based activation motif (ITAM) that is essential for TCR signaling. Phosphorylation of CD3's ITAM enables the CD3 chain to bind Fyn, making this kinase important in the T cell's signaling cascade.

. . . catalyzing since 10/06/06
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