IκB kinase

Activation of IκB kinase (IKK) by stress signals stimulates phosphorylation of two serine residues in the regulatory domain 0f Inhibitor of kappa B (IκB), targetting the IκB molecules for ubiquitin/proteasome degradation, and releasing NF-κB from inhibition. (Intact Inhibitor of kappa B (IκB) inactivates NF-κB by sequestering NF-κB dimers within the cytoplasm.) Physiological activities mediated by NF-κB include cellular proliferation, and inflammatory, immune, and cellular survival responses.