PTEN
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase is a phosphatase enzyme encoded by the tumor suppressor PTEN gene – for 'phosphatase and tensin homolog' (mutated in multiple advanced cancers 1).
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.[eg]
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.[eg]