phosphodiesterases
Members of the five subtypes of phosphodiesterase enzymes degrade the cyclic nucleotide, second messengers, cAMP and cGDP by hydrolyzing phosphodiester bonds, so they are important in regulation of signal transduction.
Phospodiesterase inhibitors, such as caffeine, aminophylline, theophylline and Viagra, prolong or amplify the physiological processes that are mediated by cAMP or cGDP. The phospodiester bond form the linkage between 3'-C of nucleotides and 5'-C of pentose sugars in the backbones of DNA & RNA, rendering phosphodiester bonds particularly important. 3'-phospodiesterase is important in repair of oxidative DNA damage.
Phospodiesterase inhibitors, such as caffeine, aminophylline, theophylline and Viagra, prolong or amplify the physiological processes that are mediated by cAMP or cGDP. The phospodiester bond form the linkage between 3'-C of nucleotides and 5'-C of pentose sugars in the backbones of DNA & RNA, rendering phosphodiester bonds particularly important. 3'-phospodiesterase is important in repair of oxidative DNA damage.