PIKK

The phosphoinositol kinase-related kinase (PIKK) family includes DNA-PK, ATM, ATR, FRAP1 (mTOR) and several other proteins.

mTOR (FRAP1) is a serine/threonine kinase that regulates regulates translation and cell division. The mTOR protein kinase receives stimulatory signals from nutrients as well as Ras and phosphatidylinositol-3-OH kinase (PI3K) downstream from growth factors, so it functions as a signaling molecule and a critical growth-control node.

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